McCaffrey’s Week 1 workload was 31 touches, and Week 2 injury chatter centered on a calf scare. He practiced fully late in the week and wasn’t listed on the Sunday injury report, making him a strong play against New Orleans unless a late setback arises.

The 49ers’ backfield remains in flux. If McCaffrey can’t go, Brian Robinson would step into the top role and Isaac Guerendo could mix in behind him. Shanahan offered little new detail beyond saying there was nothing to report after Week 1, keeping fantasy managers on alert for last‑minute lineup decisions.

Week 2 fantasy decisions hinge on rebound potential for Pacheco, Mason, and Swift. Pacheco faces a stingy Eagles front and could see his workload grow, while Mason has momentum in Minnesota and looks poised to seize bellcow duties. Swift must translate earlier flashes into efficient carries and strong pass-game work against Detroit, still offering PPR upside.

Beyond these three, Judkins, Warren, Ridley, Odunze, Olave, Williams, and Meyers offer viable flex or streamer appeal, depending on format and roster depth. The analysis emphasizes workload, matchup, and efficiency to guide Week 2 starts and sits.

Jaylen Warren looks like a strong Week 2 start in PPR leagues, nursing a solid floor as a high-end RB2 while sharing work with Kenneth Gainwell. The Steelers’ matchup against Seattle offers a favorable environment, especially if Gainwell continues to struggle with efficiency. Warren’s quick, decisive runs and reception upside give him steady fantasy value, with the potential to push into the top tier of Week 2 backs if the Seattle defense stays vulnerable to both the run and short passes.

If Gainwell falters, Warren could absorb a larger workload and be Pittsburgh’s featured runner, a path that raises his ceiling beyond the typical RB2 range. The combination of Pittsburgh’s backfield dynamics and Seattle’s Week 1 struggles defending backs sets Warren up to deliver solid, usable Week 2 production in most formats.

Jakobi Meyers flashed as Geno Smith's top target in Week 1, drawing 10 targets and grabbing 8 for 97 yards in a Raiders win over New England. The early connection signals a sizable target share moving forward, with Meyers functioning as a trusted possession option and big-play threat. If Brock Bowers is limited by knee injury, Meyers could push into high end WR2 territory in PPR and toward WR2 in standard formats. If Bowers suits up, Meyers remains a solid WR3 with weekly upside, especially in a Week 2 Monday night test against the Chargers.

The Week 2 matchup and the ongoing discussion around Who Should I Start underline Meyers' volatility ceiling: volume-driven weeks when the offense commits to him, with a potential spike if the supporting cast is hindered. Managers should monitor Bowers status closely as this game approaches, as it will largely dictate Meyers' week plan and fantasy viability.